When erythropoietin meddles in immune affairs.
نویسندگان
چکیده
Frank Martinez and Nicolas Pallet *Department of Intensive Care and Renal Transplantation, Necker Hospital, Paris’ Public Assistance Hospital, Paris, France; Paris Descartes University and Sorbonne Paris City, Paris, France; Department of Nephrology, and §Department of Biochemistry, Georges Pompidou European Hospital, Paris’ Public Assistance Hospital, France, Paris, France; and Institute of Health and Medical Research U1147, University Centre of the Holy Fathers, Paris, France
منابع مشابه
The Effects of Recombinant Human Erythropoietin (rHuEPO) on Antihuman Lymphocyte Antibodies Titer in Sensitized Rats
Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. Recent studies show the effects of EPO on immune system. In this study the antihuman leukocyte antibody (anti-HLA) titer were determined in five groups of rats, which had been sensitized with human lymphocyte. Also, the effects of stimulation's frequency and dose of recombinant human erythropo...
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BACKGROUND A costly component of end-stage renal disease care is anemia management with recombinant human erythropoietin. National Kidney Foundation clinical practice guidelines recommend that erythropoietin be administered subcutaneously, rather than intravenously, given that the target hemoglobin level can be maintained with a lower subcutaneous dose. Because reimbursement for erythropoietin ...
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Background: Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. New studies show the effects of EPO on immune system. Objective: In this study, the effects of pretreatment with recombinant human erythropoietin (rHuEPO) on the anti-human leukocyte antibody (anti-HLA) titer were determined. Methods: Three groups of rats were sensitized with human...
متن کاملSome Properties of Serum Obtained from Rabbits Immunized with Human Urinary Erythropoietin.
S ERA obtained from rabbits immunized with human urinary erythropoietin can neutralize the biological effects of human erythropo etin’ and erythropoietin obtained from mice, rats, sheep, and rabbits.2 Injection of such immune sera into normal mice results in a selective erythroid aplasia of the bone marrow.3 Evidence has been presented that this neutralization is not the resuit of a cytotoxic a...
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BACKGROUND Lentiviral gene transfer can provide long-term expression of therapeutic genes such as erythropoietin. Because overexpression of erythropoietin can be toxic, regulated expression is needed. Doxycycline inducible vectors can regulate expression of therapeutic transgenes efficiently. However, because they express an immunogenic transactivator (rtTA), their utility for gene therapy is l...
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ورودعنوان ژورنال:
- Journal of the American Society of Nephrology : JASN
دوره 25 9 شماره
صفحات -
تاریخ انتشار 2014